ROTENONE CAS NO.83-79-4

Rotenone is widely present in the root bark of plants. It is a highly specific substance in toxicology. It has strong touch killing and stomach poisoning effects on insects, especially the larva of butterfly butterfly, Diamondback moth and aphids. Earlier studies have shown that rotenone's mechanism of action is mainly to affect the respiration of insects, and mainly to interact with a component between NADH dehydrogenase and coenzyme Q. Rotenone inhibits the electron transport chain of the pest cells, thereby reducing the level of ATP in the organism and ultimately depriving the pest of energy supply, and then sluggish action, paralysis and slow death.

Mitochondria, NADH dehydrogenase, succinic acid, mannitol and other substances in many biological cells are sensitive to rotenone. Electron transfer from NADPH to NADH in the mitochondria of Setayria cervi is highly inhibited by rotenone, and the activity of the fumaric acid reductase system in mitochondrial particles of filaria parasite Setaria digitata is sensitive to rotenone. Rotenone and salicyloxime could inhibit the EMT of the inner mitochondria of Trypanosoma brucei brucei, thereby indirectly affecting the activity of NADH dehydrogenase. Rotenone could also inhibit the activity of NADH to cytochrome C and NADH to coQ reductase in the mitochondrial respiratory chain of Trypanosoma brucei brucei, and the inhibition rate was as high as 80% to 90%.

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